Selank and Semax: what N-acetyl and amidate mean

Selank and Semax are related synthetic heptapeptides. Our versions carry two common chemical modifications, an N-terminal acetyl group and a C-terminal amide. This guide explains the sequences, what those modifications change, and what the independent reports found. It describes chemistry only, not effects in people or animals.

Two peptides with a shared ending

Both peptides were developed at the Institute of Molecular Genetics of the Russian Academy of Sciences, and both end in the same three residues, Pro-Gly-Pro.

What “N-acetyl” and “amidate” mean

A plain peptide has a free amine group at one end (the N-terminus) and a free carboxylic acid at the other (the C-terminus). The two modifications cap both ends:

• N-acetyl (NA): an acetyl group is added to the N-terminal amine, removing its positive charge.
• Amidate: the C-terminal carboxylic acid becomes an amide, removing its negative charge.

Capping both ends is a standard technique in peptide chemistry, because many of the enzymes that break peptides down (exopeptidases) work by trimming residues from the free ends. Together the two changes add about 41 g/mol to the molecular weight.

What the lab reports show

Both are supplied as 30 mg of lyophilised powder in a 3 mL vial. The current reports:

Storage and handling

• Unopened, long term: −20 °C, protected from light.
• Unopened, short term: 2–8 °C for up to several weeks.
• Let the vial reach room temperature before opening.
• After reconstitution: keep at 2–8 °C and write the preparation date on the vial.

In our range

Peptides

NA-Selank Amidate 30mg

$229.00Add to cart

Peptides

NA-Semax Amidate 30mg

$229.00Add to cart

For laboratory research use only. Neither peptide is registered on the Australian Register of Therapeutic Goods, and nothing on this page describes use in humans or animals.